Making Cancer Care More Equitable with Diagnostics

Genomic Ancestry Research

We partner with researchers across the globe to conduct retrospective studies leveraging our unique cancer dataset to understand if there are biological differences by ancestry that can help to design more personalized approaches to care in the future. Our large and diverse datasets help guide patients and physicians to more accurate diagnostics and targeted clinical trials across all genomic ancestral populations. See our recent research

Awareness, Access & Education Initiatives

We remain deeply committed to addressing education, awareness and access challenges in testing through Foundation Medicine-driven programs and services, such as our FoundationAccess^TM program, our work with Medicaid programs and patient-specific resources and services and through our giving initiatives and coalition involvement. We are dedicated to providing genomic testing and personalized oncology solutions to all patients, regardless of their socioeconomic status. In line with this commitment, we are working to expand access to our testing for Medicaid-insured populations.

Working with Medicaid

By working with Medicaid programs across the country, we are helping to enable more patients to obtain access to personalized cancer treatment plans based on their unique genetic profiles. Medicaid coverage of our tests continues to grow, making it easier for patients with limited resources to benefit from the latest advances in precision medicine. This builds on the broad national and regional coverage for our FoundationOne®CDx and FoundationOne®Liquid CDx tests, including Medicare, Medicare Advantage, and the Veterans Administration (VA).

Call for Grants Notification

Foundation Medicine issued a formal Call for Grants Notification (CGN) in Q4 2022. The CGN sought projects/initiatives aimed at increasing biomarker testing education, awareness, and access among underserved populations in the U.S. LUNGevity Foundation and Moffitt Cancer Center were selected to receive the grant and will be using the funds to develop patient-friendly educational materials that provide accurate and balanced information about personalized healthcare and genomic testing.

Research organized by disease area

PAN CANCER

1. Leveraging existing data to identify ancestry-associated features across multiple cancer types.https://aacrjournals.org/cancerres/article/82/12_Supplement/1166/702694/Abstract-1166-Leveraging-existing-data-to-identify

2. Disparities According to Genetic Ancestry in the Use of Precision Oncology Assays. https://doi.org/10.1056/NEJMc2213457

3. Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.https://doi.org/10.1016/j.ccell.2020.04.012

4. Not all TMB assays are the same: Clinical validity of robust algorithmic germline filtering.https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00090-9

CRC

5. Comprehensive genomic profiling (CGP) defines the genomic landscape of colorectal cancer (CRC) in individuals of African ancestry.https://www.annalsofoncology.org/article/S0923-7534(19)30527-7/fulltext

6. The Genomics of Colorectal Cancer in Populations with African and European Ancestry.https://pubmed.ncbi.nlm.nih.gov/35176763/

NSCLC

7. Ancestry-based differences in gene alterations in non–small cell lung cancer: Real-world data using genetic ancestry analysis.https://doi.org/10.1200/jco.2022.40.16_suppl.9125

PROSTATE

8. Ancestral characterization of the genomic landscape, comprehensive genomic profiling utilization, and treatment patterns may inform disparities in advanced prostate cancer: A large-scale analysis.https://doi.org/10.1200/jco.2021.39.15_suppl.5003

SKIN

9. Prevalence of High-Risk Nonvaccine Human Papillomavirus Types in Advanced Squamous Cell Carcinoma Among Individuals of African vs Non-African Ancestry.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111484/

BREAST

10. Comparison of PIK3CA mutation prevalence in breast cancer across predicted ancestry populations.https://doi.org/10.1200/po.22.00341

BLOOD

11. Genomic Ancestry in B-Cell Lymphoid Malignancies.https://ashpublications.org/blood/article/136/Supplement%201/5/470927/Genomic-Ancestry-in-B-Cell-Lymphoid-Malignancies

We know what’s next because, at Foundation Medicine, we’re the ones creating it.

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