We partner with researchers across the globe to conduct retrospective studies leveraging our unique cancer dataset to understand if there are biological differences by ancestry that can help to design more personalized approaches to care in the future. Our large and diverse datasets help guide patients and physicians to more accurate diagnostics and targeted clinical trials across all genomic ancestral populations. See our recent research
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Making Cancer Care More Equitable with Diagnostics
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Genomic Ancestry Research
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Call for Grants Notification
Foundation Medicine issued a formal Call for Grants Notification (CGN) in Q4 2022. The CGN sought projects/initiatives aimed at increasing biomarker testing education, awareness, and access among underserved populations in the U.S. LUNGevity Foundation and Moffitt Cancer Center were selected to receive the grant and will be using the funds to develop patient-friendly educational materials that provide accurate and balanced information about personalized healthcare and genomic testing.
Research organized by disease area
BLOOD
Genomic Ancestry in B-Cell Lymphoid Malignancies.
https://ashpublications.org/blood/article/136/Supplement%201/5/470927/Genomic-Ancestry-in-B-Cell-Lymphoid-Malignancies
BREAST
Comparison of PIK3CA mutation prevalence in breast cancer across predicted ancestry populations.
https://doi.org/10.1200/po.22.00341
The impact of coding germline variants on contralateral breast cancer risk and survival.
https://pubmed.ncbi.nlm.nih.gov/36827971/
COLORECTAL
Comprehensive genomic profiling (CGP) defines the genomic landscape of colorectal cancer (CRC) in individuals of African ancestry.
https://www.annalsofoncology.org/article/S0923-7534(19)30527-7/fulltext
The Genomics of Colorectal Cancer in Populations with African and European Ancestry.
https://pubmed.ncbi.nlm.nih.gov/35176763/
GASTROINTESTINAL
Comparative Genomic Analysis of Intrahepatic Cholangiocarcinoma: Biopsy Type, Ancestry, and Testing Patterns.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417854/
Comprehensive genomic profiling (CGP) of gall bladder adenocarcinoma (GBAC) in patients from distinct ancestral populations.
https://www.annalsofoncology.org/article/S0923-7534(19)58935-9/fulltext
Landscape of BRAF mutation classes in intrahepatic cholangiocarcinoma.
https://ascopubs.org/doi/abs/10.1200/JCO.2023.41.4_suppl.599
Molecular profiling of biliary tract cancers in patients of African and European ancestries.
https://www.annalsofoncology.org/article/S0923-7534(23)02243-3/fulltext
GENITOURINARY
Age-, sex-, and race-related differences in outcomes of patients with muscle-invasive bladder cancer treated with radical cystectomy: The role of biology versus access to standard medical care.
https://ascopubs.org/doi/abs/10.1200/JCO.2023.41.16_suppl.4522
Comparative Genomic Landscape of Urothelial Carcinoma of the Bladder Among Patients of East and South Asian Genomic Ancestry.
https://pubmed.ncbi.nlm.nih.gov/37196060/
Comparative genomic alterations (GA) landscape in urothelial carcinoma of the bladder (UCB) in patients of South Asian ancestry (SAS).
https://www.annalsofoncology.org/article/S0923-7534(22)03788-7/fulltext
GYNECOLOGIC
Advanced cancers amongst individuals of African ancestry exhibit an almost five-fold higher prevalence of high-risk HPV types not covered by the current 9-valent vaccine.
https://www.sciencedirect.com/science/article/abs/pii/S0090825821008027
Clinicopathologic and genomic characterization of PD-L1-positive uterine cervical carcinoma.
https://pubmed.ncbi.nlm.nih.gov/33637877/
Comprehensive genomic profiling (CGP) of uterine carcinosarcomas (UCS) reveals unique ancestry features and both molecular similarities and differences when compared to endometrial serous carcinomas.
https://www.sciencedirect.com/science/article/pii/S0090825823009988?via%3Dihub
Molecular analysis of endometrial serous carcinoma reveals distinct clinicopathologic and genomic subgroups.
https://pubmed.ncbi.nlm.nih.gov/34998597/
LUNG
Ancestry-based differences in gene alterations in non–small cell lung cancer: Real-world data using genetic ancestry analysis.
https://doi.org/10.1200/jco.2022.40.16_suppl.9125
Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation.
https://pubmed.ncbi.nlm.nih.gov/37062002/
PROSTATE
Ancestral characterization of the genomic landscape, comprehensive genomic profiling utilization, and treatment patterns may inform disparities in advanced prostate cancer: A large-scale analysis.
https://doi.org/10.1200/jco.2021.39.15_suppl.5003
Genomic Profiling of Prostate Cancers from Men with African and European Ancestry.
https://pubmed.ncbi.nlm.nih.gov/32651179/
SKIN
Prevalence of High-Risk Nonvaccine Human Papillomavirus Types in Advanced Squamous Cell Carcinoma Among Individuals of African vs Non-African Ancestry.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111484/
PAN CANCER
Circulating Cell-Free DNA Yield and Circulating-Tumor DNA Quantity from Liquid Biopsies of 12 139 Cancer Patients.
https://pubmed.ncbi.nlm.nih.gov/34626187/
Comprehensive Analysis of Genetic Ancestry and Its Molecular Correlates in Cancer.
https://doi.org/10.1016/j.ccell.2020.04.012
Determining patient ancestry based on targeted tumor comprehensive genomic profiling.
https://aacrjournals.org/cancerres/article/79/13_Supplement/1599/633744/Abstract-1599-Determining-patient-ancestry-based
Disparities According to Genetic Ancestry in the Use of Precision Oncology Assays.
https://doi.org/10.1056/NEJMc2213457
Genomic characteristics and predicted ancestry of NTRK1/2/3 and ROS1 fusion-positive tumours from >165,000 pan-solid tumours.
https://www.annalsofoncology.org/article/S0923-7534(19)58665-3/fulltext#articleInformation
Genomic context of NTRK1/2/3 fusion-positive tumours from a large real-world population.
https://www.nature.com/articles/s41698-021-00206-y
Leveraging existing data to identify ancestry-associated features across multiple cancer types.
https://aacrjournals.org/cancerres/article/82/12_Supplement/1166/702694/Abstract-1166-Leveraging-existing-data-to-identify
Mutational Landscapes of Smoking-Related Cancers in Caucasians and African Americans: Precision Oncology Perspectives at Wake Forest Baptist Comprehensive Cancer Center.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562225/
Not all TMB assays are the same: Clinical validity of robust algorithmic germline filtering.
https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00090-9
Pan-cancer analysis of sex differences and their associations with ancestry and genomic biomarkers in a large comprehensive genomic profiling dataset.
https://aacrjournals.org/cancerres/article/80/16_Supplement/2337/641903/Abstract-2337-Pan-cancer-analysis-of-sex
Somatic genome alterations in cancer as compared to inferred patient ancestry.
https://aacrjournals.org/cancerres/article/78/13_Supplement/1227/625489/Abstract-1227-Somatic-genome-alterations-in-cancer
Tumor sequencing of African ancestry reveals differences in clinically relevant alterations across common cancers.
https://www.cell.com/cancer-cell/pdf/S1535-6108(23)00359-8.pdf